The diagnostic and prognostic significance of flow cytometric bone marrow assessment in myelodysplastic syndromes according to the European LeukemiaNet recommendations in single‐centre real‐life experience

Introduction This analysis attempts to determine the diagnostic and prognostic value of bone marrow (BM) evaluation by multiparameter flow cytometry in patients with myelodysplastic syndrome (MDS). Materials methods The study group consisted who underwent process years 2008-2017 due cytopenia finally were diagnosed MDS (n = 71). comparative included same period, whose definitive diagnosis was other than 39). Flow cytometric BM performed following recommendations European LeukemiaNet (ELN) all patients. Results median number immunophenotypic abnormalities found on granulocytes significantly higher compared [2 (range 0-5) vs 0 0-2); P < .0001]. Similarly, Ogata score 0-4) 1 0-3); Since disturbances CD11b/HLA-DR CD11b/CD13 more common patients, extended these abnormalities, what resulted its sensitivity (82%) while preserving high specificity (87%). positive correlation between risk determined Revised International Prognostic Scoring System (P .017). Conclusions Our results indicate that usefulness may be increased including abnormal expression granulocytes. Moreover, our findings suggest significance MDS.